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Huanbiao Mo

Professor, Chair    

PhD, Nutritional Sciences, University of Wisconsin-Madison

MS, Plant Physiology, Shanghai Institute of Plant Physiology, Chinese Academy of Sciences

BS, Biochemistry, Fudan University


Selected Publications

Journal articles

  1. Mo H, Jeter R, Backmann A, Yount ST, Shen CL, Yeganehjoo H. (2019) The potential of isoprenoids in adjuvant cancer therapy to reduce adverse effects of statins. Frontiers in Pharmacology. doi: 10.3389/fphar.2018.01515.
  2. Shen CL, Wang S, Yang S, Tomison MD, Abbasi M, Hao L, Scott S, Khan MS, Romero AW, Felton CK, Mo H. (2018) A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake.BMC Complementary and Alternative Medicine. 18:198. PMID: 29954374. PMCID: PMC6022510. doi: 10.1186/s12906-018-2263-0.
  3. Shen CL, Kaur G, Wanders D, Sharma S, Tomison M, Ramalingam L, Chung E, Moustaid-Moussa N, Mo H, Dufour J. (2018) Annatto-extracted tocotrienols improve glucose homeostasis and bone properties in high-fat diet-induced type II diabetic mice by decreasing the inflammatory response. Scientific Reports. 8:11377. PMID: 30054493. PMCID: PMC6063954. doi: 10.1038/s41598-018-29063-9.
  4. Shen CL, Yang S, Tomison MD, Romero AW, Felton CK, Mo H. (2018) Tocotrienols supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial. Osteoporosis International. 29:881-91. PMID: 29330573. doi: 10.1007/s00198-017-4356-x.
  5. Chung E, Mo H, Wang S, Zu Y, Elfakhani M, Rios SR, Chyu MC, Yang RS, Shen CL. (2018) Potential roles of vitamin E in age-related changes in skeletal muscle health. Nutrition Research. 49:23-6. PMID: 29420990. doi: 10.1016/j.nutres.2017.09.005.
  6. Shen CL, Klein A, Chin KY, Mo H, Tsai P, Yang RS, Chyu MC, Ima-Nirwana S. (2017) Tocotrienols for bone health: a translational approach.Annals of the New York Academy of Sciences. 1401:150-65. PMID: 28891093. doi: 10.1111/nyas.13449.
  7. Yeganehjoo H, DeBose-Boyd R, McFarlin BK, Mo H. (2017) Synergistic impact of d-δ-tocotrienol and geranylgeraniol on the growth and HMG CoA reductase of human DU145 prostate carcinoma cells. Nutrition and Cancer. 69:682-91. PMID 28362175. doi: 10.1080/01635581.2017.1299876.
  8. Chen L, Mo H, Zhao L, Gao W, Wang S, Cromie MM, Lu C, Wang JS, Shen CL. (2017) Therapeutic properties of green tea against environmental insults. Journal of Nutritional Biochemistry. 40:1-13. PMID 27723473. PMCID: PMC5124528. doi: 10.1016/j.jnutbio.2016.05.005.
  9. Torabi S, Yeganehjoo H, Shen CL, Mo H. (2016) PPARγ downregulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes. Nutrition Research. PMID 27884413; doi: 10.1016/j.nutres.2016.11.001.
  10. Shen CL, Mo H, Yang S, Wang S, Felton CK, Tomison MD, Soelaiman IN. (2016) Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose-response double-blinded placebo-controlled randomized trial. BMJ Open. 6:e012572. PMID 28011809. doi: 10.1136/bmjopen-2016-012572.
  11. Torabi S, Mo H. (2016) trans, trans-Farnesol as a mevalonate-derived inducer of murine 3T3-F442A preadipocyte differentiation. Experimental Biology and Medicine (Maywood). 241:493-500. PMID: 26660152. doi: 10.1177/1535370215620855.
  12. Cao HH, Chu JH, Kwan HY, Su T, Yu H, Cheng BCY, Fu X, Guo H, Li T, Tse AKW, Chou GX, Mo H, Yu ZL. (2016) Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. Scientific Reports. PMID 26911838. PMCID: PMC4766576. doi: 10.1038/srep21731.
  13. Xia W, Mo H. (2016) Potential of tocotrienols in the prevention and therapy of Alzheimer’s disease. Journal of Nutritional Biochemistry 31:1-9. PMID 27133418.
  14. Samuel F, Reddy J, Kaimal R, Segovia V, Mo H, Hynds DL. (2014) Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones. Molecular Neurobiology 50:49-59. PMID: 24515839. PMCID: PMC4128908. doi: 10.1007/s12035-014-8653-5.
  15. Elfakhani M, Torabi S, Hussein D, Mills N, Verbeck G, Mo H. (2014) Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes. Experimental Biology and Medicine (Maywood). 238:293-301. PMID: 24477821. doi: 10.1177/1535370213517614.
  16. Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su S, Bapat P, Kwun IS, Shen CL. (2014) Novel insights of dietary polyphenols and obesity. Journal of Nutritional Biochemistry 25:1-18. PMID: 24314860. doi: 10.1016/j.jnutbio.2013.09.001.
  17. Mo H. (2013) The “one-two punch” of isoprenoids to inflammation (editorial). Journal of Nutritional Disorders & Therapy. 3:e109.
  18. Shen CL, Kwun IS, Wang S, Mo H, Chen L, Jenkins M, Brackee G, Chen CH, Chyu MC. (2013) Function and mechanisms of green tea catechins in regulating bone remodeling. Current Drug Targets 14:1619-1630. PMID: 24041336.
  19. Soelaiman IN, Das S, Shuid AN, Mo H, Mohamed N. (2013) Use of medicinal plants and natural products for treatment of osteoporosis and its complications (editorial). Evidence-Based Complementary and Alternative Medicine PMID: 23476703. PMCID: PMC3582079.
  20. Chin KY, Mo H, Soelaiman IN. (2013) A review of the possible mechanisms of action of tocotrienol – a potential antiosteoporotic agent. Current Drug Targets 14:1533-1541. PMID: 23859472.
  21. Goktas Z, Moustaid-Moussa N, Shen CL, Boylan M, Mo H, Wang S. (2013) Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Frontiers in Endocrinology 4:69. PMID: 23772224.
  22. Fernandes N, Yeganehjoo H, Katuru R, DeBose-Boyd RA, Morris LL, Michon R, Yu ZL, Mo H. (2013) Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Experimental Biology and Medicine (Maywood) 238:1265-1274. PMID 24006306. doi: 10.1177/1535370213492693.
  23. Cruz PM, Mo H, McConathy W, Sabnis NA, Lacko AG. (2013) The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings relevant to future cancer therapeutics. Frontiers in Pharmacology of Anti-Cancer Drugs 4:119. PMID: 24093019. PMCID: PMC3782849. doi: 10.3389/fphar.2013.00119.
  24. Jones S, Fernandes N, Yeganehjoo H, Katuru R, Qu H, Yu ZL, Mo H. (2013) β-Ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. Nutrition and Cancer 65:600-610. PMID: 23659452. doi: 10.1080/01635581.2013.776091.

Book chapters

  1. Shen CL, Zhang, J, Mo H, Chyu MC, Tang L, Wang JS. (in press) Green tea catechins and tocotrienols in bone protection: evidence from preclinical studies, in Natural Products and Remedies: Evidence based evaluation for use in human disease prevention and treatment. Ed S.S. Prabhakar. Springer Nature publisher.
  2. Shen CL, Mo H, Smith BJ, Chen CH, Chen L, Chyu MC, Kwun IS. (2014) Green tea and other fruit polyphenols attenuate deterioration of bone microarchitecture, in Polyphenols in Chronic Diseases and Mechanisms of Action of Polyphenols. eds R.R. Watson, V.R. Preedy & S. Zibadi. Elsevier publisher, volume 1, chapter 52.
  3. Mo H, Elfakhani M, Shah A, Yeganehjoo H. (2013) Mevalonate-suppressive tocotrienols for cancer chemoprevention and adjuvant therapy, in Tocotrienols: vitamin E beyond tocopherols. 2nd, eds B. Tan, R.R. Watson & V.R. Preedy. CRC Press, Boca Raton, FL. Page 135-149.

Selected Invited Lectures/Oral Presentations

Tocotrienol and adipogenesis: role of the mevalonate pathway. The 4th Guangzhou International Symposium for Nutrition and Health and the 2016 Annual Conference of Geriatric Nutrition Branch of Chinese Nutrition Society, Guangzhou, China, 2016.

Exploration of tocotrienols for the prevention of Alzheimer’s disease. Chinese Congress on Gerontology and Health Industry, Suzhou, China, 2016.

Mevalonate pathway in cancer and adipogenesis. Center for Diagnostics and Therapeutics, Georgia State University, 2016.

The potential application of isoprenoids in cancer and obesity. Department of Chemistry, Georgia State University, 2015.

Dietary isoprenoids and cancer prevention. Westlake Frontiers in Nutrition Research Training Program, Zhejiang University, HangZhou, China, 2013.

Synergistic suppression of the mevalonate pathway and its potential applications. Wenzhou Medical College, Wenzhou, China, 2013.

Tumor-suppressive activity of geranylgeraniol in vitro. University of North Texas Health Science Center, Fort Worth, TX, 2013

Tumor-suppressive activity of geranylgeraniol in vitro. 12th International Conference on Functional Food Ingredients and Nutraceuticals in Chronic Disease, Southern Methodist University, Dallas, TX. 2012.

Tocotrienol’s effect on the HMGR pathway. 2nd International Tocotrienol Symposium, in conjunction with 103rd American Oil Chemist Society annual meeting, Long Beach, CA. 2012.



Elson CE, Mo H. Acyclic monoterpenoid derivatives. US patent 6,303,654.

Elson CE, Jung M, Mo H. Acyclic isoprenoid ether derivatives as chemotherapeutics. US patent 6,566,397.

Mo H, Elson CE, Peffley DM, Hentosh PM. Composition and method for treating cancer. US patent 7,074,825.


Chair, Diet and Cancer Research Interest Section, American Society for Nutrition

Secretary/Vice President/President/Past President, North America Chinese Society for Nutrition

Co-Chair, China Interest Group, American Society for Nutrition

Membership Committee, Society for Experimental Biology and Medicine (term ends 2017)

Member, Gerontological Society of America

Member, American Society for Nutrition

Associate Editor, Nutrition & Metabolism