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Huanbiao Mo, PhD

Professor    Department Chair    
Education

PhD, Nutritional Sciences, University of Wisconsin-Madison

MS, Plant Physiology, Shanghai Institute of Plant Physiology, Chinese Academy of Sciences

BS, Biochemistry, Fudan University

Biography

Selected Publications

Journal articles

  1. Shen CL, Klein A, Chin KY, Mo H, Tsai P, Yang RS, Chyu MC, Ima-Nirwana S. (in press) Tocotrienols for bone health: a translational approach. Annals of the New York Academy of Sciences.
  2. Yeganehjoo H, DeBose-Boyd R, McFarlin BK, Mo H. (2017) Synergistic impact of d-δ-tocotrienol and geranylgeraniol on the growth and HMG CoA reductase of human DU145 prostate carcinoma cells. Nutrition and Cancer. 69:682-91. PMID 28362175. doi: 10.1080/01635581.2017.1299876.
  3. Torabi S, Yeganehjoo H, Shen CL, Mo H. (2016) PPARγ downregulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes. Nutrition Research. PMID 27884413; doi: 10.1016/j.nutres.2016.11.001.
  4. Shen CL, Mo H, Yang S, Wang S, Felton CK, Tomison MD, Soelaiman IN. (2016) Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose-response double-blinded placebo-controlled randomized trial. BMJ Open. 6:e012572. PMID 28011809. doi: 10.1136/bmjopen-2016-012572.
  5. Chen L, Mo H, Zhao L, Gao W, Wang S, Cromie MM, Lu C, Wang JS, Shen CL. (2016) Therapeutic properties of green tea against environmental insults. Journal of Nutritional Biochemistry. 40:1-13. PMID 27723473. PMCID: PMC5124528. doi: 10.1016/j.jnutbio.2016.05.005.
  6. Torabi S, Mo H. (2016) trans, trans-Farnesol as a mevalonate-derived inducer of murine 3T3-F442A preadipocyte differentiation. Experimental Biology and Medicine (Maywood). 241:493-500. PMID: 26660152. doi: 10.1177/1535370215620855.
  7. Cao HH, Chu JH, Kwan HY, Su T, Yu H, Cheng BCY, Fu X, Guo H, Li T, Tse AKW, Chou GX, Mo H, Yu ZL. (2016) Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. Scientific Reports. PMID 26911838. PMCID: PMC4766576. doi: 10.1038/srep21731.
  8. Xia W, Mo H. (2016) Potential of tocotrienols in the prevention and therapy of Alzheimer’s disease. Journal of Nutritional Biochemistry 31:1-9.
  9. Samuel F, Reddy J, Kaimal R, Segovia V, Mo H, Hynds DL. (2014) Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones. Molecular Neurobiology 50:49-59. PMID: 24515839. PMCID: PMC4128908. doi: 10.1007/s12035-014-8653-5.
  10. Elfakhani M, Torabi S, Hussein D, Mills N, Verbeck G, Mo H. (2014) Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes. Experimental Biology and Medicine (Maywood). 238:293-301. PMID: 24477821. doi: 10.1177/1535370213517614.
  11. Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su S, Bapat P, Kwun IS, Shen CL. (2014) Novel insights of dietary polyphenols and obesity. Journal of Nutritional Biochemistry 25:1-18. PMID: 24314860. doi: 10.1016/j.jnutbio.2013.09.001.
  12. Mo H. (2013) The “one-two punch” of isoprenoids to inflammation (editorial). Journal of Nutritional Disorders & Therapy. 3:e109.
  13. Shen CL, Kwun IS, Wang S, Mo H, Chen L, Jenkins M, Brackee G, Chen CH, Chyu MC. (2013) Function and mechanisms of green tea catechins in regulating bone remodeling. Current Drug Targets 14:1619-1630. PMID: 24041336.
  14. Soelaiman IN, Das S, Shuid AN, Mo H, Mohamed N. (2013) Use of medicinal plants and natural products for treatment of osteoporosis and its complications (editorial). Evidence-Based Complementary and Alternative Medicine PMID: 23476703. PMCID: PMC3582079.
  15. Chin KY, Mo H, Soelaiman IN. (2013) A review of the possible mechanisms of action of tocotrienol – a potential antiosteoporotic agent. Current Drug Targets 14:1533-1541. PMID: 23859472.
  16. Goktas Z, Moustaid-Moussa N, Shen CL, Boylan M, Mo H, Wang S. (2013) Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Frontiers in Endocrinology 4:69. PMID: 23772224.
  17. Fernandes N, Yeganehjoo H, Katuru R, DeBose-Boyd RA, Morris LL, Michon R, Yu ZL, Mo H. (2013) Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Experimental Biology and Medicine (Maywood) 238:1265-1274. PMID 24006306. doi: 10.1177/1535370213492693.
  18. Cruz PM, Mo H, McConathy W, Sabnis NA, Lacko AG. (2013) The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings relevant to future cancer therapeutics. Frontiers in Pharmacology of Anti-Cancer Drugs 4:119. PMID: 24093019. PMCID: PMC3782849. doi: 10.3389/fphar.2013.00119.
  19. Jones S, Fernandes N, Yeganehjoo H, Katuru R, Qu H, Yu ZL, Mo H. (2013) β-Ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. Nutrition and Cancer 65:600-610. PMID: 23659452. doi: 10.1080/01635581.2013.776091.
  20. Mo H, Yeganehjoo H, Shah A, Mo WK, Soelaiman IN, Shen C. (2012) Mevalonate-suppressive dietary isoprenoids for bone health. Journal of Nutritional Biochemistry 23:1543-1551. PMID: 22981371. doi: 10.1016/j.jnutbio.2012.07.007.
  21. Shen CL, von Bergen V, Chyu MC, Jenkins MR, Mo H, Chen CH, Kwun IS. (2012) Fruits and dietary phytochemicals in bone protection. Nutrition Research 32:897-910. PMID: 23244535. doi: 10.1016/j.nutres.2012.09.018.
  22. Zeng S, Wang L, Chen T, Wang Y, Mo H, Qu H. (2012) Direct analysis in real time mass spectrometry and multivariate data analysis: a novel approach to rapid identification of analytical markers for quality control of traditional Chinese medicine preparation. Analytica Chimica Acta 733:38-47. PMID: 22704374. doi: 10.1016/j.aca.2012.04.025.

Book chapters

  1. Shen CL, Mo H, Smith BJ, Chen CH, Chen L, Chyu MC, Kwun IS. (2014) Green tea and other fruit polyphenols attenuate deterioration of bone microarchitecture, in Polyphenols in Chronic Diseases and Mechanisms of Action of Polyphenols. eds R.R. Watson, V.R. Preedy & S. Zibadi. Elsevier publisher, volume 1, chapter 52.
  2. Mo H, Elfakhani M, Shah A, Yeganehjoo H. (2013) Mevalonate-suppressive tocotrienols for cancer chemoprevention and adjuvant therapy, in Tocotrienols: vitamin E beyond tocopherols. 2nd, eds B. Tan, R.R. Watson & V.R. Preedy. CRC Press, Boca Raton, FL. Page 135-149.

Selected Invited Lectures/Oral Presentations

Tocotrienol and adipogenesis: role of the mevalonate pathway. The 4th Guangzhou International Symposium for Nutrition and Health and the 2016 Annual Conference of Geriatric Nutrition Branch of Chinese Nutrition Society, Guangzhou, China, 2016.

Exploration of tocotrienols for the prevention of Alzheimer’s disease. Chinese Congress on Gerontology and Health Industry, Suzhou, China, 2016.

Mevalonate pathway in cancer and adipogenesis. Center for Diagnostics and Therapeutics, Georgia State University, 2016.

The potential application of isoprenoids in cancer and obesity. Department of Chemistry, Georgia State University, 2015.

Dietary isoprenoids and cancer prevention. Westlake Frontiers in Nutrition Research Training Program, Zhejiang University, HangZhou, China, 2013.

Synergistic suppression of the mevalonate pathway and its potential applications. Wenzhou Medical College, Wenzhou, China, 2013.

Tumor-suppressive activity of geranylgeraniol in vitro. University of North Texas Health Science Center, Fort Worth, TX, 2013

Tumor-suppressive activity of geranylgeraniol in vitro. 12th International Conference on Functional Food Ingredients and Nutraceuticals in Chronic Disease, Southern Methodist University, Dallas, TX. 2012.

Tocotrienol’s effect on the HMGR pathway. 2nd International Tocotrienol Symposium, in conjunction with 103rd American Oil Chemist Society annual meeting, Long Beach, CA. 2012.

 


Patents

Elson CE, Mo H. Acyclic monoterpenoid derivatives. US patent 6,303,654.

Elson CE, Jung M, Mo H. Acyclic isoprenoid ether derivatives as chemotherapeutics. US patent 6,566,397.

Mo H, Elson CE, Peffley DM, Hentosh PM. Composition and method for treating cancer. US patent 7,074,825.

Memberships

American Society for Nutrition
Co-Chair, China Interest Group
2013-present

Society for Experimental Biology and Medicine
Membership Committee
2013-present

American Society for Nutrition Awards Program
Senior Educator & Mentor Nominating Panel
2013

American Society for Nutrition Awards Program
Senior Investigator (Group I) Nominating Panel
2012

North America Chinese Society for Nutrition
Secretary General
2012-present

American Association for Cancer Research
Member
2011-present

Society for Experimental Biology and Medicine
Member
2011-present

American Society for Nutrition
Chair, Diet and Cancer Research Interest Section
2010-2011

American Society for Nutrition
Member
2001-present

Institute for Cancer Research
University of North Texas Health Science Center
Member
2001

Center for Nutrition, Health and Food Genomics
Institute of Food Science and Engineering
Texas A & M University – College Station
Member, Advisory Board
2001-2006